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Volume: 38
Number: 4
Index: December 2010
Clinical Focus:Respiratory Care
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December 2010
Clinical Focus: Respiratory Medicine
  • Asthma and the athlete
    • Vocal cord dysfunction
    • Exercise-induced asthma
    • Exercise-induced bronchospasm
  • COPD
    • Obesity and COPD
    • Relationship between COPD and nutrition intake
  • Treatment options for steroid-induced osteoporosis in men
  • Treatments for asthma
    • Bronchodilators, anticholinergics
    • Corticosteroids
    • Metered-dose vs other types of inhalers
  • Respiratory infections in winter sports athletes
  • Asthma in elite athletes
  • Pulmonary rehabilitation and physical activity
  • Fitness and long-term oxygen therapy/lung transplantation
  • Airflow function and the metabolic syndrome
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doi: 10.3810/psm.2010.04.1763
The Physician and Sportsmedicine: Volume 38: No.1
The Effect of Long-Term, High-Volume Aerobic Exercise Training on Postprandial Lipemia and Oxidative Stress
Richard J. Bloomer, PhD; Kelsey H. Fisher-Wellman, MS; And Heather K. Bell, MS
Abstract: Aims We have previously found no effect of moderate-volume aerobic exercise training (~3 hrs·wk−1) on postprandial oxidative stress. It is possible that a higher volume of exercise is needed to impact postprandial oxidative stress in young, otherwise healthy individuals. Our purpose was to compare blood triglycerides (TAGs) and oxidative stress biomarkers in 10 healthy untrained and 10 healthy highly aerobically trained (eg, ≥ 40 miles running·wk−1 or ≥ 150 miles cycling·wk−1) men and women following ingestion of a lipid meal. Methods Blood samples were collected before (in a 10-hour fasted state), and 1, 2, 4, and 6 hours after ingestion of a lipid load (heavy whipping cream at 1 g·kg−1). Blood samples were analyzed for TAGs, malondialdehyde (MDA), hydrogen peroxide (H2O2), and nitrate/nitrite (NOx). Results No training status or interaction effects were noted for TAGs, MDA, H2O2, or NOx (P > 0.05). However, a time effect was noted for TAGs (P = 0.01), with values higher at 2 hours (67 ± 6 mg·dL−1) compared with premeal (41 ± 6 mg·dL−1). A time effect was also noted for H2O2 (P = 0.0001), with values higher at 2 hours (24 ± 3 μmol·L−1), 4 hours (23 ± 3 μmol·L−1), and 6 hours (21 ± 3 μmol·L−1) compared with premeal (7 ± 2 μmol·L−1). The time effect for MDA approached significance (P = 0.07), with values peaking at 4 hours post-meal (1.59 ± 0.16 μmol·L−1) compared with premeal (0.99 ± 0.15 μmol·L−1). Conclusion These data indicate that aerobic exercise training (even when performed at a relatively high volume) does not attenuate postprandial lipemia or oxidative stress as compared with no exercise when healthy men and women consume a lipid load in the form of heavy whipping cream. Fasting TAG values may be most important in this regard. It is possible that long-term exercise may be capable of attenuating postprandial lipemia or oxidative stress in older individuals, those with chronic disease, or those with elevated fasting TAG values. Future work is needed to confirm these hypotheses.

Keywords: triglycerides; reactive oxygen species; nutrition; exercise


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