[The Physician and Sportsmedicine]

Contraindications to Athletic Participation: Cardiac, Respiratory, and Central Nervous System Conditions

James L. Moeller, MD

THE PHYSICIAN AND SPORTSMEDICINE - VOL 24 - NO. 8 - AUGUST 96

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This is the first of two articles on contraindications to athletic participation. The second, on eye, spine, gastrointestinal, infectious disease, and dermatologic issues, will appear in the September issue.

In Brief: Sports activities promote health and fitness for most participants, but for some, activity can complicate an illness or even be fatal. This article, the first of a two- part series on contraindications to activity, examines the cardiac, respiratory, and central nervous system conditions that warrant activity disqualification and provides guidelines about when it's safe for patients to participate.

Physicians across the country perform thousands of preparticipation physical exams annually. The goal of these exams is to identify patients at risk for increased morbidity and mortality through athletic participation (1-4). The physician's duty is not only to disqualify patients from activities that increase the risk of morbidity and mortality (2,4,5), but to allow them to participate whenever possible (4). To do this, the physician may need to suggest alternative activities that do not pose a threat to the patient (1,3,4), or treat the patient for problems that may pose a risk (3). The physician must also disqualify patients from activities when their participation would pose an unusual risk of injury or illness to other participants (2). Though there are many situations that require physicians to make activity recommendations, only about 1% of athletes are disqualified from athletics (6-8).

This article begins a two-part series that will provide specific recommendations for disqualification from athletic participation. This first installment deals with classification of sports and the cardiovascular, respiratory, and central nervous systems. The second article will address reasons for disqualification per'taining to the visual system, axial skeleton, gastrointestinal system, blood, and skin, and will discuss controversial areas. Specific injuries and recommendations for disqualification pertaining to the appendicular skeleton are beyond the scope of this series. This series is not meant to be all-inclusive, but to cover the most common reasons for disqualification from athletics. Each patient's case should be viewed on an individual basis (5).

Scaling Sports Activities

Most people classify sports as either contact or noncontact. The American Academy of Pediatrics Committee on Sports Medicine (9) has further divided sports into the following five categories:

  1. contact/collision,
  2. limited contact/impact,
  3. noncontact strenuous,
  4. noncontact moderately strenuous, and
  5. noncontact nonstrenuous (table 1: not shown).
The 26th Bethesda Conference report (10) classifies sports according to peak dynamic and static components during competition (table 2: not shown). Both of these classification systems are referred to throughout this article. Of course, some sports by their nature pose some risk of serious injury or even death, even if the classification systems indicate they are safe for persons with a particular medical condition (eg, archery and riflery have obvious inherent risks).

Cardiovascular Issues

Guidelines for participation in competitive athletics for patients with cardiovascular disease are described in the 26th Bethesda Conference report (10). This section will review some of the situations in which disqualification should be considered as outlined by the Bethesda Conference and supported by other sources. A more complete listing of recommendations regarding the cardiovascular system is provided in the Bethesda guidelines.

Hypertrophic cardiomyopathy (HCM). The leading cause of sudden cardiac death in athletes younger than 30 (10-15), HCM is characterized by a thickened ventricular septum (greater than 15 mm) as compared with the ventricular free wall (10,14). Left ventricular cavity size is generally unchanged but left ventricular filling and compliance are impaired (14).

Patients may have a history of exertional syncope (11,13,14), dizziness (8,14), or chest pain with activity. The physical exam may reveal a systolic murmur that increases with the Valsalva maneuver (11,13,14). If the patient's history and physical exam findings raise the suspicion of HCM, further diagnostic work-up including echocardiography, electrocardiography (ECG) (10,11,13,14), and possibly Holter monitoring (10,13) or genetic testing should be considered (10).

Symptomatic patients with HCM should not participate in competitive sports (10,11,14). Athletes who are asymptomatic should only be allowed to participate in low-intensity sports (10). Screening echocardiography is not recommended (10,11).

Aortic stenosis. Recommendations for athletic participation in patients with congenital aortic stenosis are based on the severity of the disease. Disease severity is graded by the severity of patients' symptoms and the systolic pressure gradient as determined by echocardiography. In some instances, cardiac catheterization may be required to assess the pressure gradient and the severity of disease.

In mild aortic stenosis (up to 20 mm Hg peak systolic pressure gradient at rest) the recommendation is that patients may participate in all competitive sports as long as they have a normal ECG, normal stress tolerance, and no exercise-induced chest pain, syncope, or arrhythmia (10). For patients with moderate disease (21 to 49 mm Hg peak systolic gradient), only low static/low-to-moderate dynamic and moderate static/low dynamic competitive sports should be allowed, and then only under certain conditions (4,10). No competitive sports are recommended for patients who have severe aortic stenosis (50 mm Hg peak systolic gradient or higher) (10).

Coarctation of the aorta. Almost all patients who have moderate or severe disease will undergo either surgical repair or the balloon procedure in their youth. Severity grading is based on the arm-leg pressure gradient, physical exam, exercise testing, and echocardiography (10).

Patients who have mild disease may participate in all competitive sports as long as there are no large collateral vessels or severe aortic root dilatation. Also, a normal exercise test, small pressure gradient, and peak systolic blood pressure no greater than 230 mm Hg should be documented. Patients may participate only in low-intensity sports if their pressure gradient is greater than 20 mm Hg or the peak systolic blood pressure is greater than 230 mm Hg (4,10).

For patients who are treated for this condition, participation in sports may resume 6 months after treatment if the pressure gradient is no greater than 20 mm Hg and the peak systolic blood pressure is no greater than 230 mm Hg. High-intensity static exercise and collision sports should be avoided for at least 1 year after treatment (10).

Infective carditis. This condition is usually caused by coxsackievirus B. Diagnosis is based on the patient history, which usually includes a respiratory illness that is complicated by other symptoms such as fatigue, dyspnea (10,13), syncope, palpitations, arrhythmias, or acute congestive heart failure (10). Chest x-ray and echocardiograpy (10,13) may help make the diagnosis, as may endomyocardial biopsy (10).

Because infective carditis may cause dangerous arrhythmias, it is recommended that patients be withdrawn from sports for 6 months after the onset of symptoms. Patients may return to competition when ventricular function is normal, cardiac dimensions are normal, and no clinically relevant arrhythmias are present on Holter monitoring (10).

Uncontrolled hypertension. Blood pressure readings that indicate hypertension differ by age group (table 3: not shown). Hypertension is diagnosed by three separate elevated blood pressure readings (10).

Patients who have mild-to-moderate hypertension without end-organ damage and concomitant heart disease should not be restricted from competitive sports (4,10). In fact, moderate dynamic and static exercise should be encouraged to help decrease blood pressure (10). Those who have severe hypertension should be restricted from high static sports until hypertension is controlled with medications and lifestyle modification (4,10).

Mitral valve prolapse. This condition is relatively common, with a prevalence of approximately 5% (10,13,16). Many athletes who have mitral valve prolapse participate in high-level competitive sports. Patients who have mitral valve prolapse may participate in all competitive sports unless:

  • a history of arrhythmogenic syncope is documented,
  • a family history of sudden death associated with mitral valve prolapse is noted (10,16),
  • repetitive forms of supraventricular tachycardia or ventricular arrhythmia are present with exercise,
  • there is moderate or marked mitral regurgitation (4,10,16), or
  • a prior embolic event has occurred (10).
Patients who fit any of the above criteria may participate only in low-intensity competitive sports (10,16).

Arrhythmia Concerns

Many arrhythmias that are discovered on the preparticipation physical exam are benign and do not require activity modification. However, it is useful to review the more serious rhythm disturbances that pose a risk to active young people.

Wolff-Parkinson-White (WPW) syndrome. Evaluation of these patients should include ECG (8,17), Holter monitoring (10,18) during athletic activity, exercise testing (10,17,18), and echocardiograpy. Patients older than 20 who have no structural heart disease, palpitations, or tachycardia may participate in all competitive sports (10). Those who have syncope, near syncope, or episodes of atrial fibrillation or flutter and have a maximum heart rate at rest of greater than 240 beats per minute are restricted to low-intensity competitive sports and should be considered for radiofrequency catheter ablation of the accessory pathway (10,17).

Premature ventricular contractions (PVCs). If PVCs increase during exercise testing such that they produce symptoms, patients can participate only in low-intensity competitive sports. Patients whose PVCs are suppressed by drug therapy and those who have structural heart disease and PVCs are also limited to low-intensity competitive sports (10).

Ventricular tachycardia. Noninvasive tests for ventricular tachycardia include ECG, 24-hour Holter monitoring, exercise testing, and echocardiography. If testing documents ventricular tachycardia, patients should not compete in any sport for 6 months after the last episode (10). Patients may return to athletics if there have been no clinical recurrences, ventricular tachycardia is not reproducible by exercise or exercise testing, and no structural heart disease is present (10,19). Only low-intensity competitive sports are allowed if structural heart disease and ventricular tachycardia are present (10).

Ventricular flutter, ventricular fibrillation. Patients who have ventricular flutter or ventricular fibrillation may participate only in low-intensity competitive sports and only if there have been no episodes of ventricular flutter or fibrillation during 6 months of treatment (10).

Atrioventricular block. Patients who have first-degree block may participate at all levels of competition if they are asymptomatic and the block does not worsen with exercise. Those who have second-degree type I (Wenckebach) block may participate in all sports if the block does not worsen with exercise. A block that worsens with exercise indicates a need for further evaluation (10).

Patients who have second degree type II (Mobitz) block or congenital complete heart block may participate in all sports if they are asymptomatic (10,19), and if heart rate increases with exertion with no or only occasional PVCs and no ventricular tachycardia. For participation clearance, a narrow QRS complex must be present on ECG (10).

Long QT syndrome. Patients who have this condition are at risk for sudden death with activity and should be restricted from all competitive sports (10,19).

Respiratory Recommendations

Though asthma is by far the most common respiratory condition that can limit activity in young people, physicians should be prepared to make participation recommendations about some of the less common conditions: tuberculosis, pulmonary insufficiency, and pneumothorax.

Tuberculosis. One condition that should bar an athlete from all competitive sports is active tuberculosis (4). The reason is the risk of transmission of tuberculosis to competitors or teammates.

Asthma. There is no need to restrict patients' activity as long as the asthma is well controlled. Patients whose asthma is poorly controlled should be restricted from contact sports and strenuous noncontact sports (4); this holds true for chronic and exercise-induced asthma. These patients may return to full activities once medication controls the asthmatic condition.

Pulmonary insufficiency. As the population ages, many people will remain active into their 60s and beyond. Because of this, there will be many patients with chronic illnesses who wish to remain active. For patients who have pulmonary insufficiency, there is no need to restrict activity as long as exercise testing does not cause unsatisfactory deoxygenation. If significant deoxygenation occurs with exercise, these patients should be restricted to nonstrenuous noncontact sports (9).

Pneumothorax. Primary spontaneous pneumothorax is a condition that occurs usually in lean males (20), and is believed to be caused by the rupture of unsuspected alveolar blebs from apical bullous disease (19,20). Because of the increased risk of recurrence, only nonstrenuous activities are allowed for patients who have undergone conservative treatment for primary spontaneous pneumothorax (4). Those who wish to return to more strenuous or even contact activities after their pneumothorax resolves with conservative measures should be counseled on the risks of recurrence; however, those who are treated with thoracotomy or other invasive procedures may usually resume all sports (4) after 2 to 4 weeks (19). It is important that patients realize there is an increased risk of recurrence, especially on the contralateral side. Patients should be advised to discontinue contact sports when pneumothorax recurs (4).

CNS Caveats

Questioning patients about their seizure and concussion history helps reveal red flags that might point to a need for activity restriction because of central nervous system problems.

Seizure disorder. Seizures during physical exertion are infrequent, and only one rare type of seizure disorder, tonic seizure, has been shown to be induced by activity (19). Patients whose seizures are well controlled with medication may participate in all sports (4,9). Head trauma may precipitate seizure activity in patients who have epilepsy, but this should not prevent medically well-controlled patients from participating in contact sports if they follow normal safeguards and use adequate head protection (21). Sports such as swimming, weight lifting, archery, and riflery require special consideration because seizure during activity could result in death (9). Patients whose seizures are poorly controlled should be barred from contact/collision sports and limited contact/impact sports (4,9). These patients also should avoid swimming, weight lifting, archery, and riflery (9).

Concussion. There are many different classification systems for concussion, and none is perfect. Several classification systems are compared in table 4. Many gray areas exist in each classification system regarding return-to-play criteria. Most physicians agree that a patient should be disqualified from the current activity if sensorium does not clear quickly or if other symptoms and signs are present, such as loss of consciousness, post-traumatic amnesia, confusion, dizziness, or headache (22-27). Evaluation may require a CT scan or referral to a neurosurgeon, depending on severity (25).

__________________________________________________________________________________
Table 4. Comparison of Classifications of Concussion 
__________________________________________________________________________________
Cantu (22)     Colorado (23)      Nelson (26)       Kulund (24)     Torg (27) 
Grade 1 (mild) Grade 1            Grade O           Mild            Grade 1 
No LOC; PTA    Confusion without  Head struck or    Stunned, dazed; 'Bell rung,' 
less than 30   amnesia, no LOC    moved rapidly;    no confusion,   short-term 
min                               not stunned       dizziness,      confusion, 
                                  or dazed          nausea,         unsteady gait, 
                                  initially;        or visual       dazed appearance,
                                  subsequently      disturbance;    no LOC or 
                                  complains of      feels well      posttraumatic  
                                  headache and      after 1 or 2    amnesia
                                  difficulty        min; 
                                  concentrating     coordinated               
Grade 2        Grade 2            Grade 1           Moderate        Grade 2 
(moderate)     Confusion with     Stunned or dazed  LOC, mental     PTA, vertigo 
LOC less than  amnesia, no LOC    initially; no LOC confusion, 
5 min or                          or amnesia; 'bell retrograde 
PTA less than                     rung,' sensorium  amnesia,
30 min                            clears less       tinnitus, 
                                  than 1 min        dizziness;
                                                    skill recovery 
                                                    may be rapid 
Grade 3        Grade 3            Grade 2           Severe          Grade 3 
(severe)       LOC                Headache, cloudy  Longer LOC,     PTA, retrograde
LOC greater                       sensorium greater headache,       amnesia, vertigo
than or equal                     than 1 min,       confusion,      
to 5 min                          no LOC,           PTA, 
or PTA greater                    may have          retrograde 
than or equal to                  tinnitus or       amnesia 
24 hr                             amnesia, may be 
                                  irritable, 
                                  hyperexcitable, 
                                  confused, dizzy 
                                  Grade 3                           Grade 4 
                                  LOC less than                     Immediate,
                                  1 min, not comatose               transient LOC
                                  (arousable with 
                                  noxious stimuli), 
                                  demonstrates grade 
                                  2 symptoms during 
                                  recovery 
                                  Grade 4                           Grade 5 
                                  LOC greater than                  Paralytic coma,
                                  1 min, not  comatose,             cardiorespiratory
                                  demonstrates grade 2              arrest
                                  symptoms during  
                                  recovery 
                                                                    Grade 6 Death
__________________________________________________________________________________
Key: LOC = loss of consciousness, PTA = posttraumatic amnesia
__________________________________________________________________________________
 

Determinations about return to play should be made case-by-case depending on the severity of the injury. A patient continuing to have symptoms from a prior concussion should not be allowed to participate in contact sports until those symptoms clear (22,23,28.29). How long the patient must be asymptomatic before return to play is also controversial. Guidelines for return to play after a concussion as outlined by Cantu (22) are presented in table 5.

__________________________________________________________________________________
Table 5. Guidelines for Return to Play After Concussion
__________________________________________________________________________________
Grade           1st concussion          2nd concussion           3rd concussion
__________________________________________________________________________________
1 (mild)        May return to           Return to play in 2 wk   Terminate
                play if asymptomatic*   if asymptomatic for 1 wk season; return
                for 1 wk                                         next season if
                                                                 asymptomatic
2 (moderate)    Return to play after    Minimum of 1 mo; may     Terminate
                asymptomatic for 1 wk   return to play then if   season; return
                                        asymptomatic for 1 wk;   next season if
                                        consider terminating     asymptomatic
                                        season
3 (severe)      Minimum of 1 mo; may    Terminate season; may
                return to play if       return to play next
                asymptomatic for 1 wk   season if asymptomatic
__________________________________________________________________________________
*	No headache, dizziness, or impaired orientation, concentration, or memory during 
rest or exertion
Reprinted from Cantu RC: Guidelines for return to contact sports after a cerebral 
concussion. Phys Sportmed 1986;14(10):75-83
__________________________________________________________________________________

Returning to play too soon puts patients at risk for second impact syndrome, a condition that may occur when a second head injury is sustained before the symptoms of a first head injury have completely cleared (28,30-32). Rapid cerebral swelling leads to rapid neurologic deterioration and death (28,31). The second impact can be minor and not even directly to the head (ie, a Valsalva maneuver or a strong blow to the chest) (28,30).

On a Safe Track

Despite published recommendations that say certain patients should be disqualified from athletic participation, each patient's case should be considered individually. All efforts should be made to allow athletes to participate so long as they do not increase the risk of injury or death to themselves or others.

References

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  2. Smith DM: Preparticipation physical examination. Sports Medicine and Arthroscopy Review 1995;3(2): 84-94
  3. Tanji JL: The preparticipation physical examination for sports. Am Fam Physician 1990;42(3):397-402
  4. Tucker JB, Marron JT: The qualification/disqualification process in athletics. Am Fam Physician 1984;29 (2):149-154
  5. Mitten MJ, Maron BJ: Legal considerations that affect medical eligibility for competitive athletes with cardiovascular abnormalities and acceptance of Bethesda Conference recommendations. Med Sci Sports Exerc 1994;26(10 suppl):S238-S241
  6. Fields KB: Clearing athletes for participation in sports: the North Carolina Medical Society Sports Medicine Committee's recommended examination. NC Med J 1994;55(4): 116-121
  7. Magnes SA, Henderson JM, Hunter SC: What conditions limit sports participation? Experience with 10,540 athletes. Phys Sportsmed 1992;20(5):143-160
  8. Rifat SF, Ruffin MT IV, Gorenflo DW: Disqualifying criteria in a preparticipation sports evaluation. J Fam Pract 1995;41(1):42-50
  9. American Academy of Pediatrics Committee on Sports Medicine: Recommendations for participation in competitive sports. Pediatrics 1988;81(5): 737-739
  10. 26th Bethesda Conference: Recommendations for determining eligibility for competition in athletes with cardiovascular abnormalities. J Am Coll Cardiol 1994;24(4):845-899
  11. Ades PA: Preventing sudden death: cardiovascular screening of young athletes. Phys Sportsmed 1992; 20(9):75-89
  12. Allison TG: Counseling athletes at risk for sudden death. Phys Sportsmed 1992;20(6):140-149
  13. Bernhardt DT, Landry GL: Chest pain in active young people: Is it cardiac? Phys Sportsmed 1994;22(6):70-85
  14. Maron BJ: Hypertrophic cardiomyopathy in athletes: catching a killer. Phys Sportsmed 1993;21(9):83-91
  15. Sherman C: Sudden death during exercise: How great is the risk for middle-aged and older adults? Phys Sportsmed 1993;21(9):93-102
  16. Washington RL: Mitral valve prolapse in active youth. Phys Sportsmed 1993;21(1):136-144
  17. Cantwell JD, Watson A: Does your Wolff-Parkinson-White patient need to slow down? Phys Sportsmed 1992;20(7):115-129
  18. Cantwell JD: Palpitations with exercise. Phys Sportsmed 1994;22(4):83-84
  19. McKeag DB, Hough DO: Primary Care Sports Medicine. Dubuque, Iowa, Brown & Benchmark, 1993
  20. Simoneaux SF, Murphy BJ, Tehranzadeh J: Spontaneous pneumothorax in a weight lifter: a case report. Am J Sports Med 1990;18(6):647-648
  21. Cowart VS: Should epileptics exercise? Phys Sportsmed 1986;14(9):183-191
  22. Cantu RC: Guidelines for return to contact sports after a cerebral concussion. Phys Sportsmed 1986;14(10):75-83
  23. Kelly JP, Nichols JS, Filley CM, et al: Concussion in sports: guidelines for the prevention of catastrophic outcome. JAMA 1991;266(20):2867-2869
  24. Kulund DN: The Injured Athlete. Philadelphia, JB Lippincott Co, 1982
  25. Maroon JC, Bailes JE, Yates A, et al: Assessing closed head injuries. Phys Sportsmed 1992;20(4):37-44
  26. Nelson WE, Jane JA, Gieck JH: Minor head injury in sports: a new system of classification and management. Phys Sportsmed 1984;12(3):103-107
  27. Torg JS: Athletic injuries to the head, neck and face. Philadelphia, Lea and Febiger, 1982
  28. Cantu RC: Second impact syndrome: immediate management. Phys Sportsmed 1992;20(9):55-66
  29. Stenger A: Keeping concussions from being fatal. Phys Sportsmed 1992;20(1):54-56
  30. Cantu RC, Voy R: Second impact syndrome: a risk in any contact sport. Phys Sportsmed 1995;23(6):27-34
  31. Roberts WO: Who Plays? Who Sits? Managing concussions on the sidelines. Phys Sportsmed 1992;20(6):66-72
  32. Shell D, Carico GA, Patton RM: Case Report: can subdural hematoma result from repeated minor head injury? Phys Sportsmed 1993;21(4):74-84

Dr Moeller is associate director of Primary Care Sports Medicine at the University of Pittsburgh Medical Center in Pittsburgh. He is an assistant professor in the departments of family medicine and orthopaedic surgery. He is a member of the American College of Sports Medicine and the American Medical Society for Sports Medicine. Address correspondence to James L. Moeller, MD, University Orthopaedics, Inc, Kaufman Bldg, Suite 1010, 3471 Fifth Ave, Pittsburgh, PA 15213; e-mail to [email protected].


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